The age of the woman is an important factor for the issue of IVF over 40. However, by applying preimplantation genetic diagnosis to the women who are aged over 40 and considered to have good ovarian capacity, it is possible to achieve pregnancy 25-30%.
If the hormone tests which are performed on the 3rd day of the menstruation and the ultrasonography showing that ovarian capacity and functions are appropriate, it is possible to apply IVF until the age of 45. However, it is recommended to investigate whether embryos are normal in terms of chromosomes with preimplantation genetic diagnosis method.
Nowadays, in spite of the wide range of treatment which is available for all types of male infertility, the biggest obstacle for the treatment is the age of the woman. The ovarian reserve of a new born girl, which is between one to two million at that time, decreases to 250-300 thousand within the first menstrual period and keep decreasing until the menopause. The advancing age, decreases the reserve especially after the age of 37; the loss rate in the ovarian reserve is evident. In addition to that, the quality of the eggs deteriorates with advancing age, which reduces the chance of getting pregnant and having a healthy child. Therefore, miscarriages in the early stages of pregnancy are more common than the younger aged women. The age of woman and the low numbered eggs as a result of aging are the most important factors affecting success. 25-30 % success in pregnancy is acquired with the women who are over 40 and are accepted to have good ovarian capacity by applying preimplantation genetic diagnosis.
‘Preimplantation genetic diagnosis’ can be applied in order to increase the chances of continuing pregnancy and having a healthy child. With this technique, the chromosomes, which are observed to be more problematic at that age, are investigated before transferring to the uterus so that transfer of the abnormal embryos is avoided. Loss in the ovarian reserve may sometimes occur at younger ages, the ovarian reserve of older women might be higher than expected. Thus, it is very significant to identify the ovarian reserve of women within extensive examination, ultrasonography and hormone tests in order to be able to reveal the success chances and inform the patients. The patient who knows that the appropriate treatment method is chosen and her confidence and cooperation facilitate the implementation of the treatment by reducing the psychological stress.