What is PGD?
PGD (Preimplantation Genetic Diagnosis) is a technique that is used to evaluate all chromosomes of the embryo before their transfer into the womb. For the genetic selection to be guaranteed, it should be done on the 5th day of the embryo development (which is called the blastocyte stage) the reason of that is that it’s less harmful and more accurate with less mosaicism issues and there would be more cells available for testing. You might wonder why most of clinics do the PGD on the 3rd day, the reason is it’s less of a cost to them, but with Crown IVF your health is a priority and we guarantee 100% accurate results.
How is PGD done?
First step is gently removing one or two cells from healthy looking embryos (blastocyte stage) using a biopsy pipette. Then genetic testing begins. People might wonder if it is harmful to the embryo, but with our team everything is done with professionally and with cautious. Finally, based on the results of the PGD, embryos with normal genes are selected and transferred to the patient.
Who is PGD for?
- Those with a minimum of two to threefailed attempts
- Those who have had recurrent miscarriages
- Individuals with hereditary diseases within family history
- Those who have advanced maternal age
- People with sex chromosomes transmitting diseases
- Those with HLA (human leukocyte antigen) typing
- Couples who want to choose the gender of their child for family balancing purposes (PGT-A)
Another Examination technique:
NGS for Gender Selection
It is an advanced technique used in PGD that analyzes all 24 chromosomes (22 autosomes, X and Y) providing detailed information of the embryo’s genetic health and sex. The process is quite similar:
Embryo biopsy (usually at the blastocyst stage) removes 5–10 cells from the trophectoderm.
The DNA from these cells is amplified and sequenced using NGS.
The resulting data includes:
- Total chromosome count (to check for aneuploidies)
- Presence of XX (female) or XY (male) chromosomes
Then transfer embryos of the desired sex.
For more information and free consultation feel free to contact us.